Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(27) + succinate + formaldehyde + CO(2)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Lysine-specific demethylase 6A (preferred)
PDBe Complex ID:
PDB-CPX-127530 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 6A
Molecule details ›
Chain: A
Length: 531 amino acids
Theoretical weight: 60.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 531 amino acids
Theoretical weight: 60.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O15550 (Residues: 880-1401; Coverage: 37%)
Sequence domains:
- JmjC domain, hydroxylase
- Lysine-specific demethylase 6/UTY, C-terminal helical domain
- KDM6, GATA-like
