› 3b0o

X-ray diffraction
1.61Å resolution

Crystal structure of alpha-lactalbumin

Released:
DOI: 10.2210/pdb3b0o/pdb
PDB entry 3b0o coloured by chain, front view.
PDB entry 3b0o coloured by chain, side view.
PDB entry 3b0o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the stability perturbations induced by N-terminal variation in human and goat α-lactalbumin.
Makabe K, Nakamura T, Kuwajima K
Protein Eng Des Sel 26 165-70 (2013)
PMID: 23155056

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132931 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-lactalbumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00709 (Residues: 21-142; Coverage: 99%)
Gene names: LALBA, LYZL7
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21
Unit cell:
a: 32.917Å b: 68.161Å c: 46.212Å
α: 90° β: 92.22° γ: 90°
R-values:
R R work R free
0.155 0.153 0.193
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Functional Analogy in Human Metabolism: Enzymes with Different Biological Roles or Functional Redundancy?
Piergiorge et al. (2017)