› 3b0q

X-ray diffraction
2.1Å resolution

Human PPAR gamma ligand binding domain in complex with MCC555

Released:
DOI: 10.2210/pdb3b0q/pdb
PDB entry 3b0q coloured by chain, front view.
PDB entry 3b0q coloured by chain, side view.
PDB entry 3b0q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tomioka D, Hashimoto H, Sato M, Shimizu T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 274 amino acids
Theoretical weight: 31.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 231-504; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand MC5 1 x MC5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: C2
Unit cell:
a: 93.252Å b: 59.812Å c: 117.846Å
α: 90° β: 103.89° γ: 90°
R-values:
R R work R free
0.2 0.198 0.229
Expression system: Escherichia coli

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