3b29

X-ray diffraction
3.2Å resolution

Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside

Released:
Source organism: Homo sapiens
Primary publication:
Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-β-D-selenomaltoside.
Acta Crystallogr Sect F Struct Biol Cryst Commun 67 1666-73 (2011)
PMID: 22139193

Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
PDBe Complex ID:
PDB-CPX-172606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene C4 synthase Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.41 KDa
Source organism: Homo sapiens
Expression system: Schizosaccharomyces pombe
UniProt:
  • Canonical: Q16873 (Residues: 1-150; Coverage: 100%)
Gene name: LTC4S
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: F23
Unit cell:
a: 168.594Å b: 168.594Å c: 168.594Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.209
Expression system: Schizosaccharomyces pombe