› 3b8a

X-ray diffraction
2.95Å resolution

Crystal structure of yeast hexokinase PI in complex with glucose

Released:
DOI: 10.2210/pdb3b8a/pdb
PDB entry 3b8a coloured by chain, front view.
PDB entry 3b8a coloured by chain, side view.
PDB entry 3b8a coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised.
Kuser P, Cupri F, Bleicher L, Polikarpov I
Proteins 72 731-40 (2008)
PMID: 18260108

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138188 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-1 Chain: X
Molecule details ›
Chain: X
Length: 485 amino acids
Theoretical weight: 53.8 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P04806 (Residues: 1-485; Coverage: 100%)
Gene names: HKA, HXK1, YFR053C
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand BGC 1 x BGC
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 62.12Å b: 78.87Å c: 144.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.244

Quick links

Citations

1 review citation

Dynamic New World: Refining Our View of Protein Structure, Function and Evolution.
Mannige RV. (2014)
15 other articles

8 mentions without citation

Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier.
Ruprecht et al. (2019)
7 more