› 3bbw

X-ray diffraction
4Å resolution

crystal structure of the ErbB4 kinase in its inactive conformation

Released:
DOI: 10.2210/pdb3bbw/pdb
PDB entry 3bbw coloured by chain, front view.
PDB entry 3bbw coloured by chain, side view.
PDB entry 3bbw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ
Structure 16 460-7 (2008)
PMID: 18334220

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ERBB4 intracellular domain Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15303 (Residues: 702-1029; Coverage: 26%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: P61
Unit cell:
a: 102.746Å b: 102.746Å c: 181.335Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.305 0.302 0.354
Expression system: Spodoptera frugiperda

Quick links

Citations

29 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
28 more

9 mentions without citation

Computational algorithms for in silico profiling of activating mutations in cancer.
Jordan et al. (2019)
8 more