› 3bgg

X-ray diffraction
1.93Å resolution

Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP

Released:
DOI: 10.2210/pdb3bgg/pdb
PDB entry 3bgg coloured by chain, front view.
PDB entry 3bgg coloured by chain, side view.
PDB entry 3bgg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu Y, Tang HL, Wang XY, Kotra LP, Pai EF

Function and Biology Details

Reactions catalysed: 
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Orotidine 5'-phosphate = UMP + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine 5'-monophosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 31.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11172 (Residues: 190-480; Coverage: 61%)
Gene names: OK/SW-cl.21, UMPS
Sequence domains: Orotidine 5'-phosphate decarboxylase / HUMPS family
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand BMP 1 x BMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: C2221
Unit cell:
a: 77.596Å b: 116.886Å c: 61.985Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.211
Expression system: Escherichia coli

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