› 3bis

X-ray diffraction
2.64Å resolution

Crystal Structure of the PD-L1

Released:
DOI: 10.2210/pdb3bis/pdb
PDB entry 3bis coloured by chain, front view.
PDB entry 3bis coloured by chain, side view.
PDB entry 3bis coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.
Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN
Proc Natl Acad Sci U S A 105 3011-6 (2008)
PMID: 18287011

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192774 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death 1 ligand 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 25.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 18-239; Coverage: 81%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2221
Unit cell:
a: 73.08Å b: 92.7Å c: 141.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.292
Expression system: Escherichia coli

Quick links

Citations

60 review citations

Molecular mechanisms of T cell co-stimulation and co-inhibition.
Chen et al. (2013)
59 more

19 mentions without citation

How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals.
Westbrook et al. (2019)
18 more