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X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151698 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wee1-like protein kinase Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30291 (Residues: 291-575; Coverage: 44%)
Gene name: WEE1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand 61E 1 x 61E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P41212
Unit cell:
a: 68.859Å b: 68.859Å c: 156.238Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.247
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: a review.
Morgan et al. (2008)
2 more

8 mentions without citation

Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases.
Schmidt et al. (2017)
7 more