› 3bky

X-ray diffraction
2.61Å resolution

Crystal Structure of Chimeric Antibody C2H7 Fab in complex with a CD20 Peptide

Released:
DOI: 10.2210/pdb3bky/pdb
PDB entry 3bky coloured by chain, front view.
PDB entry 3bky coloured by chain, side view.
PDB entry 3bky coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide.
Du J, Wang H, Zhong C, Peng B, Zhang M, Li B, Hou S, Guo Y, Ding J
Mol Immunol 45 2861-8 (2008)
PMID: 18346788

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero dimer
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-233981 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
the Fab fragment of chimeric 2H7, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.22 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
the Fab fragment of chimeric 2H7, light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.14 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
B-lymphocyte antigen CD20 Chain: P
Molecule details ›
Chain: P
Length: 25 amino acids
Theoretical weight: 2.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P11836 (Residues: 163-187; Coverage: 8%)
Gene names: CD20, MS4A1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P41212
Unit cell:
a: 96.49Å b: 96.49Å c: 107.613Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.301
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

4 review citations

Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.
Rich et al. (2010)
3 more

7 mentions without citation

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Xu et al. (2018)
6 more