3bpl

X-ray diffraction
2.93Å resolution

Crystal structure of the IL4-IL4R-Common Gamma ternary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-138510 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Interleukin-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Sequence domains: Interleukin 4
Structure domains: Growth Hormone; Chain: A;
Soluble interleukin-4 receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 205 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24394 (Residues: 27-227; Coverage: 25%)
Gene names: 582J2.1, IL4R, IL4RA
Sequence domains: Interleukin-4 receptor alpha chain, N-terminal
Structure domains: Immunoglobulins
Cytokine receptor common subunit gamma Chain: C
Molecule details ›
Chain: C
Length: 199 amino acids
Theoretical weight: 23.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31785 (Residues: 56-254; Coverage: 57%)
Gene name: IL2RG
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, FUC
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 52.578Å b: 86.652Å c: 175.671Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.222 0.297
Expression system: Spodoptera frugiperda