› 3bqp

X-ray diffraction
1.3Å resolution

Crystal Structure of Human Saposin D (orthorhombic)

Released:
DOI: 10.2210/pdb3bqp/pdb
PDB entry 3bqp coloured by chain, front view.
PDB entry 3bqp coloured by chain, side view.
PDB entry 3bqp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the human ceramide activator protein saposin D.
Popovic K, Privé GG
Acta Crystallogr D Biol Crystallogr 64 589-94 (2008)
PMID: 18453694

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-D Chains: A, B
Molecule details ›
Chains: A, B
Length: 80 amino acids
Theoretical weight: 8.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07602 (Residues: 405-484; Coverage: 16%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 40.45Å b: 61.45Å c: 64.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 not available 0.234
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Lysosomal degradation of membrane lipids.
Kolter et al. (2010)
1 more

4 mentions without citation

Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants.
Walther et al. (2016)
3 more