Function and Biology Details
Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
uPA-uPAR-vitronectin complex (preferred)
PDBe Complex ID:
PDB-CPX-133251 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Urokinase-type plasminogen activator long chain A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
Sequence domains: Kringle domain
Structure domains:
Length: 135 amino acids
Theoretical weight: 15.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
- Canonical:
P00749 (Residues: 21-153; Coverage: 32%)
Sequence domains: Kringle domain
Structure domains:
Somatomedin-B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Somatomedin B domain
Length: 40 amino acids
Theoretical weight: 4.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical: P04004 (Residues: 21-60; Coverage: 9%)
Sequence domains: Somatomedin B domain
Urokinase plasminogen activator surface receptor
Molecule details ›
Chain: U
Length: 283 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59
Length: 283 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
- Canonical: Q03405 (Residues: 23-303; Coverage: 90%)
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59
