› 3btr

X-ray diffraction
2.6Å resolution

AR-NLS:Importin-alpha complex

Released:
DOI: 10.2210/pdb3btr/pdb
PDB entry 3btr coloured by chain, front view.
PDB entry 3btr coloured by chain, side view.
PDB entry 3btr coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the nuclear import of the human androgen receptor.
Cutress ML, Whitaker HC, Mills IG, Stewart M, Neal DE
J Cell Sci 121 957-68 (2008)
PMID: 18319300

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145226 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 427 amino acids
Theoretical weight: 46.3 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-496; Coverage: 81%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Androgen receptor Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 622-636; Coverage: 2%)
Gene names: AR, DHTR, NR3C4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 78.274Å b: 89.372Å c: 98.104Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.229
Expression system: Escherichia coli

Quick links

Citations

48 review citations

Alternatively spliced androgen receptor variants.
Dehm et al. (2011)
47 more

6 mentions without citation

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
5 more