› 3bxk

X-ray diffraction
2.55Å resolution

Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex

Released:
DOI: 10.2210/pdb3bxk/pdb
PDB entry 3bxk coloured by chain, front view.
PDB entry 3bxk coloured by chain, side view.
PDB entry 3bxk coloured by chain, top view.
Source organisms:
Entry authors: Mori MX, Vander Kooi CW, Leahy DJ, Yue DT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126341 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP29 (Residues: 2-149; Coverage: 99%)
Gene names: CaMI, Calm, Calm1, Cam, Cam1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
Voltage-dependent P/Q-type calcium channel subunit alpha-1A Chains: B, D
Molecule details ›
Chains: B, D
Length: 21 amino acids
Theoretical weight: 2.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O00555 (Residues: 1954-1974; Coverage: 1%)
Gene names: CACH4, CACN3, CACNA1A, CACNL1A4

Ligands and Environments

2 bound ligands:
Ligand CA 8 x CA
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 80.655Å b: 80.431Å c: 63.837Å
α: 90° β: 97.56° γ: 90°
R-values:
R R work R free
0.216 0.213 0.267
Expression systems:
  • Escherichia coli
  • Not provided

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