3c5t

X-ray diffraction
2.1Å resolution

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-150708 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glucagon-like peptide 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43220 (Residues: 24-145; Coverage: 28%)
Gene name: GLP1R
Sequence domains: Hormone receptor domain
Structure domains: GPCR, family 2, extracellular hormone receptor domain
Exendin-4 Chain: B
Molecule details ›
Chain: B
Length: 31 amino acids
Theoretical weight: 3.37 KDa
Source organism: Heloderma suspectum
Expression system: Not provided
UniProt:
  • Canonical: P26349 (Residues: 56-86; Coverage: 48%)
Sequence domains: Peptide hormone

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P3121
Unit cell:
a: 75.91Å b: 75.91Å c: 87.77Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.203 0.238
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided