› 3c8x

X-ray diffraction
1.95Å resolution

Crystal structure of the ligand binding domain of human Ephrin A2 (Epha2) receptor protein kinase

Released:
DOI: 10.2210/pdb3c8x/pdb
PDB entry 3c8x coloured by chain, front view.
PDB entry 3c8x coloured by chain, side view.
PDB entry 3c8x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Architecture of Eph receptor clusters.
Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S
Proc Natl Acad Sci U S A 107 10860-5 (2010)
PMID: 20505120

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29317 (Residues: 23-202; Coverage: 19%)
Gene names: ECK, EPHA2
Sequence domains: Ephrin receptor ligand binding domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P3121
Unit cell:
a: 92.518Å b: 92.518Å c: 41.291Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.163 0.226
Expression system: Spodoptera frugiperda

Quick links

Citations

61 review citations

Mechanisms of ephrin-Eph signalling in development, physiology and disease.
Kania et al. (2016)
60 more

9 mentions without citation

Architecture of Eph receptor clusters.
Himanen et al. (2010)
8 more