› 3cby

X-ray diffraction
1.5Å resolution

The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide

Released:
DOI: 10.2210/pdb3cby/pdb
PDB entry 3cby coloured by chain, front view.
PDB entry 3cby coloured by chain, side view.
PDB entry 3cby coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition of Wnt signaling by Dishevelled PDZ peptides.
Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS
Nat Chem Biol 5 217-9 (2009)
PMID: 19252499

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127034 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14641 (Residues: 264-354; Coverage: 12%)
Gene name: DVL2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 136.303Å b: 52.187Å c: 31.911Å
α: 90° β: 100.33° γ: 90°
R-values:
R R work R free
0.136 0.134 0.182
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Wnt/beta-catenin signaling: components, mechanisms, and diseases.
MacDonald et al. (2009)
33 more

6 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
5 more