› 3ccn

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 35.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08581 (Residues: 1047-1350; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LKG 1 x LKG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 42.058Å b: 43.44Å c: 157.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.275
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Cancer driver mutations in protein kinase genes.
Torkamani et al. (2009)
4 more

6 mentions without citation

Ten things you should know about protein kinases: IUPHAR Review 14.
Fabbro et al. (2015)
5 more