› 3ch4

X-ray diffraction
1.76Å resolution

The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution

Released:
DOI: 10.2210/pdb3ch4/pdb
PDB entry 3ch4 coloured by chain, front view.
PDB entry 3ch4 coloured by chain, side view.
PDB entry 3ch4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human phosphomevalonate kinase at 1.8 A resolution.
Chang Q, Yan XX, Gu SY, Liu JF, Liang DC
Proteins 73 254-8 (2008)
PMID: 18618710

Function and Biology Details

Reaction catalysed: 
ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172225 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphomevalonate kinase Chain: B
Molecule details ›
Chain: B
Length: 202 amino acids
Theoretical weight: 23.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15126 (Residues: 1-192; Coverage: 100%)
Gene names: PMKI, PMVK
Sequence domains: Phosphomevalonate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 93.14Å b: 32.625Å c: 61.786Å
α: 90° β: 111.01° γ: 90°
R-values:
R R work R free
0.209 0.199 0.221
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Enzymes of the mevalonate pathway of isoprenoid biosynthesis.
Miziorko HM. (2011)
4 other articles

7 mentions without citation

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse.
Hornbeck et al. (2012)
6 more