› 3chn

X-ray solution scattering

Solution structure of human secretory IgA1

Released:
DOI: 10.2210/pdb3chn/pdb
PDB entry 3chn coloured by chain, ensemble of 10 models, front view.
PDB entry 3chn coloured by chain, ensemble of 10 models, side view.
PDB entry 3chn coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity.
Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ
Mucosal Immunol 2 74-84 (2009)
PMID: 19079336

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-208531 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Immunoglobulin kappa light chain Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 214 amino acids
Theoretical weight: 23.22 KDa
Source organism: Homo sapiens
Immunoglobulin heavy constant alpha 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 475 amino acids
Theoretical weight: 51.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01876 (Residues: 1-333; Coverage: 84%)
Gene name: IGHA1
Sequence domains:
Secretory component Chain: J
Molecule details ›
Chain: J
Length: 106 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 353-458; Coverage: 14%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain
Secretory component Chain: S
Molecule details ›
Chain: S
Length: 585 amino acids
Theoretical weight: 64.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 19-603; Coverage: 78%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Quick links

Citations

6 review citations

Structure and function relationships in IgA.
Woof et al. (2011)
5 more

6 mentions without citation

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe.
Del Pozo-Yauner et al. (2023)
5 more