› 3cjj

X-ray diffraction
1.85Å resolution

Crystal structure of human rage ligand-binding domain

Released:
DOI: 10.2210/pdb3cjj/pdb
PDB entry 3cjj coloured by chain, front view.
PDB entry 3cjj coloured by chain, side view.
PDB entry 3cjj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for ligand recognition and activation of RAGE.
Koch M, Chitayat S, Dattilo BM, Schiefner A, Diez J, Chazin WJ, Fritz G
Structure 18 1342-52 (2010)
PMID: 20947022

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Advanced glycosylation end product-specific receptor Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15109 (Residues: 23-240; Coverage: 57%)
Gene names: AGER, RAGE
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 74.85Å b: 119.96Å c: 28.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.24
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications.
Ramasamy et al. (2011)
51 more

26 mentions without citation

Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs.
Twarda-Clapa et al. (2022)
25 more