› 3ckh

X-ray diffraction
2.8Å resolution

Crystal structure of Eph A4 receptor

Released:
DOI: 10.2210/pdb3ckh/pdb
PDB entry 3ckh coloured by chain, front view.
PDB entry 3ckh coloured by chain, side view.
PDB entry 3ckh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.
Qin H, Shi J, Noberini R, Pasquale EB, Song J
J Biol Chem 283 29473-84 (2008)
PMID: 18708347

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-157094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 20.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54764 (Residues: 29-209; Coverage: 19%)
Gene names: EPHA4, HEK8, SEK, TYRO1
Sequence domains: Ephrin receptor ligand binding domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Unit cell:
a: 53.749Å b: 71.121Å c: 127.004Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.228 0.287
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Eph receptors and ephrins in cancer: bidirectional signalling and beyond.
Pasquale EB. (2010)
6 more

11 mentions without citation

Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.
Bowden et al. (2009)
10 more