› 3cok

X-ray diffraction
2.25Å resolution

Crystal structure of PLK4 kinase

Released:
DOI: 10.2210/pdb3cok/pdb
PDB entry 3cok coloured by chain, front view.
PDB entry 3cok coloured by chain, side view.
PDB entry 3cok coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Atwell S, Burley SK, Houle A, Leon B, Pelletier LA, Sauder JM, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 31.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00444 (Residues: 2-275; Coverage: 28%)
Gene names: PLK4, SAK, STK18
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 84.516Å b: 102.151Å c: 63.058Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.261
Expression system: Escherichia coli BL21(DE3)

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