› 3cpt

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191596 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ragulator complex protein LAMTOR3 Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 15.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UHA4 (Residues: 2-124; Coverage: 99%)
Gene names: LAMTOR3, MAP2K1IP1, MAPKSP1, PRO2783
Sequence domains: Mitogen-activated protein kinase kinase 1 interacting
Structure domains: Dynein light chain 2a, cytoplasmic
Ragulator complex protein LAMTOR2 Chain: B
Molecule details ›
Chain: B
Length: 131 amino acids
Theoretical weight: 14.23 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9JHS3 (Residues: 2-125; Coverage: 99%)
Gene names: Lamtor2, Mapbpip, Robld3
Sequence domains: Roadblock/LC7 domain
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 44.95Å b: 63.14Å c: 75.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.201 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Survey of the year 2008: applications of isothermal titration calorimetry.
Falconer et al. (2010)
1 more

1 mention without citation

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Su et al. (2017)