› 3cs9

X-ray diffraction
2.21Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 277 amino acids
Theoretical weight: 32.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 229-500; Coverage: 24%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NIL 4 x NIL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 93.926Å b: 118.088Å c: 123.683Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.242
Expression system: Spodoptera frugiperda

Quick links

Citations

313 review citations

Cancer drug resistance: an evolving paradigm.
Holohan et al. (2013)
312 more

53 mentions without citation

A medicinal chemist's guide to molecular interactions.
Bissantz et al. (2010)
52 more