› 3cvf

X-ray diffraction
2.9Å resolution

Crystal Structure of the carboxy terminus of Homer3

Released:
DOI: 10.2210/pdb3cvf/pdb
PDB entry 3cvf coloured by chain, front view.
PDB entry 3cvf coloured by chain, side view.
PDB entry 3cvf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The postsynaptic density proteins Homer and Shank form a polymeric network structure.
Hayashi MK, Tang C, Verpelli C, Narayanan R, Stearns MH, Xu RM, Li H, Sala C, Hayashi Y
Cell 137 159-71 (2009)
PMID: 19345194

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homer protein homolog 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 79 amino acids
Theoretical weight: 9.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NSC5 (Residues: 287-361; Coverage: 21%)
Gene name: HOMER3
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: P65
Unit cell:
a: 172.029Å b: 172.029Å c: 66.446Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.252 0.287
Expression system: Escherichia coli

Quick links

Citations

55 review citations

Modeling autism by SHANK gene mutations in mice.
Jiang et al. (2013)
54 more

5 mentions without citation

The postsynaptic density proteins Homer and Shank form a polymeric network structure.
Hayashi et al. (2009)
4 more