› 3cvm

X-ray diffraction
2.02Å resolution

High resolution structure of a stable Plasminogen activator inhibitor type-1 in its protease cleaved form

Released:
DOI: 10.2210/pdb3cvm/pdb
PDB entry 3cvm coloured by chain, front view.
PDB entry 3cvm coloured by chain, side view.
PDB entry 3cvm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: a new tool for detailed interaction studies and modeling.
Jensen JK, Gettins PG
Protein Sci 17 1844-9 (2008)
PMID: 18725454

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 392 amino acids
Theoretical weight: 44.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05121 (Residues: 21-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 76.603Å b: 104.014Å c: 76.426Å
α: 90° β: 101.93° γ: 90°
R-values:
R R work R free
0.229 0.228 0.282
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Functional stability of plasminogen activator inhibitor-1.
Yasar Yildiz et al. (2014)
2 more

11 mentions without citation

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition.
Sillen et al. (2020)
10 more