› 3cyn

X-ray diffraction
2Å resolution

The structure of human GPX8

Released:
DOI: 10.2210/pdb3cyn/pdb
PDB entry 3cyn coloured by chain, front view.
PDB entry 3cyn coloured by chain, side view.
PDB entry 3cyn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kavanagh KL, Johansson C, Yue WW, Kochan G, Pike ACW, Murray J, Roos AK, Filippakopoulos P, von Delft F, Arrowsmith CH, Wikstrom M, Edwards AM, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-186242 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable glutathione peroxidase 8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 189 amino acids
Theoretical weight: 21.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TED1 (Residues: 44-209; Coverage: 79%)
Gene names: GPX8, UNQ847/PRO1785
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand SO4 6 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 90.688Å b: 120.854Å c: 75.603Å
α: 90° β: 119.38° γ: 90°
R-values:
R R work R free
0.172 0.171 0.199
Expression system: Escherichia coli BL21(DE3)

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