› 3d0e

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152087 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-beta serine/threonine-protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 39.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31751 (Residues: 146-480; Coverage: 70%)
Gene name: AKT2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand G93 2 x G93
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P32
Unit cell:
a: 116.489Å b: 116.489Å c: 45.119Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.246
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Engelman JA. (2009)
10 more

33 mentions without citation

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
32 more