3d2u

X-ray diffraction
2.21Å resolution

Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor

Released:
Primary publication:
Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor.
Proc Natl Acad Sci U S A 105 10095-100 (2008)
PMID: 18632577

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-140175 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Glycoprotein UL18 Chains: A, E
Molecule details ›
Chains: A, E
Length: 281 amino acids
Theoretical weight: 31.66 KDa
Source organism: Human betaherpesvirus 5
UniProt:
  • Canonical: P08560 (Residues: 21-301; Coverage: 80%)
Gene names: H301, UL18
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, F
Molecule details ›
Chains: B, F
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Leukocyte immunoglobulin-like receptor subfamily B member 1 Chains: D, H
Molecule details ›
Chains: D, H
Length: 198 amino acids
Theoretical weight: 22.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8NHL6 (Residues: 24-221; Coverage: 32%)
Gene names: ILT2, LILRB1, LIR1, MIR7
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
Actin, cytoplasmic 1, N-terminally processed Chains: C, G
Molecule details ›
Chains: C, G
Length: 9 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60709 (Residues: 170-178; Coverage: 2%)
Gene name: ACTB

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 52.366Å b: 98.11Å c: 172.147Å
α: 90° β: 98.46° γ: 90°
R-values:
R R work R free
0.241 0.241 0.259
Expression system: Not provided