3d48

X-ray diffraction
2.5Å resolution

Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-134124 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Prolactin Chain: P
Molecule details ›
Chain: P
Length: 188 amino acids
Theoretical weight: 21.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01236 (Residues: 40-227; Coverage: 95%)
Gene name: PRL
Sequence domains: Somatotropin hormone family
Structure domains: Growth Hormone; Chain: A;
Prolactin receptor Chain: R
Molecule details ›
Chain: R
Length: 211 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16471 (Residues: 25-234; Coverage: 35%)
Gene name: PRLR
Sequence domains: Erythropoietin receptor, ligand binding
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P65
Unit cell:
a: 125.35Å b: 125.35Å c: 69.82Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.218 0.295
Expression system: Escherichia coli