3d5o

X-ray diffraction
2.8Å resolution

Structural recognition and functional activation of FcrR by innate pentraxins

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-219211 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serum amyloid P-component Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls
Low affinity immunoglobulin gamma Fc region receptor II-a Chain: F
Molecule details ›
Chain: F
Length: 177 amino acids
Theoretical weight: 20.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12318 (Residues: 37-207; Coverage: 60%)
Gene names: CD32, FCG2, FCGR2A, FCGR2A1, IGFR2
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 64.197Å b: 143.477Å c: 161.588Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.207 0.279
Expression system: Escherichia coli