› 3d8d

X-ray diffraction
2.2Å resolution

Crystal structure of the human Fe65-PTB1 domain

Released:
DOI: 10.2210/pdb3d8d/pdb
PDB entry 3d8d coloured by chain, front view.
PDB entry 3d8d coloured by chain, side view.
PDB entry 3d8d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human Fe65-PTB1 domain.
Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K
J Biol Chem 283 23113-20 (2008)
PMID: 18550529

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-126155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid beta precursor protein binding family B member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 16.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 366-505; Coverage: 20%)
Gene names: APBB1, FE65, RIR
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

2 bound ligands:
Ligand HG 6 x HG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 43.756Å b: 79.574Å c: 83.974Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.252
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Fe65 matters: new light on an old molecule.
Minopoli et al. (2012)
2 more

3 mentions without citation

Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.
Mulvihill et al. (2011)
2 more