› 3d8e

X-ray diffraction
2.8Å resolution

Crystal structure of the human Fe65-PTB1 domain (trigonal crystal form)

Released:
DOI: 10.2210/pdb3d8e/pdb
PDB entry 3d8e coloured by chain, front view.
PDB entry 3d8e coloured by chain, side view.
PDB entry 3d8e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human Fe65-PTB1 domain.
Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K
J Biol Chem 283 23113-20 (2008)
PMID: 18550529

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid beta precursor protein binding family B member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 148 amino acids
Theoretical weight: 16.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 366-505; Coverage: 20%)
Gene names: APBB1, FE65, RIR
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: R3
Unit cell:
a: 145.89Å b: 145.89Å c: 79.051Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.24 0.304
Expression system: Escherichia coli

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Citations

3 review citations

Fe65 matters: new light on an old molecule.
Minopoli et al. (2012)
2 more