› 3d90

X-ray diffraction
2.26Å resolution

Crystal structure of the human progesterone receptor ligand-binding domain bound to levonorgestrel

Released:
DOI: 10.2210/pdb3d90/pdb
PDB entry 3d90 coloured by chain, front view.
PDB entry 3d90 coloured by chain, side view.
PDB entry 3d90 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins.
Petit-Topin I, Turque N, Fagart J, Fay M, Ulmann A, Gainer E, Rafestin-Oblin ME
Mol Pharmacol 75 1317-24 (2009)
PMID: 19289570

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 676-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand NOG 2 x NOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 58.87Å b: 65.31Å c: 70.62Å
α: 90° β: 96.01° γ: 90°
R-values:
R R work R free
0.231 0.231 0.279
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Progesterone receptor targeting with radiolabelled steroids: an approach in predicting breast cancer response to therapy.
Cunha et al. (2013)
14 other articles

8 mentions without citation

Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: method and benchmark study.
Da et al. (2014)
7 more