› 3d94

X-ray diffraction
2.3Å resolution

Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP

Released:
DOI: 10.2210/pdb3d94/pdb
PDB entry 3d94 coloured by chain, front view.
PDB entry 3d94 coloured by chain, side view.
PDB entry 3d94 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.
Wu J, Li W, Craddock BP, Foreman KW, Mulvihill MJ, Ji QS, Miller WT, Hubbard SR
EMBO J 27 1985-94 (2008)
PMID: 18566589

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139911 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 34.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08069 (Residues: 986-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand D94 1 x D94
1 modified residue:
Ligand MHO 1 x MHO

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: R32
Unit cell:
a: 208.182Å b: 208.182Å c: 50.853Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.236
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

The molecular details of cytokine signaling via the JAK/STAT pathway.
Morris et al. (2018)
9 more

18 mentions without citation

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.
Wu et al. (2008)
17 more