› 3dem

X-ray diffraction
2.3Å resolution

CUB1-EGF-CUB2 domain of HUMAN MASP-1/3

Released:
DOI: 10.2210/pdb3dem/pdb
PDB entry 3dem coloured by chain, front view.
PDB entry 3dem coloured by chain, side view.
PDB entry 3dem coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.
Teillet F, Gaboriaud C, Lacroix M, Martin L, Arlaud GJ, Thielens NM
J Biol Chem 283 25715-25724 (2008)
PMID: 18596036

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155806 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mannan-binding lectin serine protease 1 heavy chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P48740 (Residues: 20-297; Coverage: 41%)
Gene names: CRARF, CRARF1, MASP1, PRSS5
Sequence domains: CUB domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 88.692Å b: 110.232Å c: 190.587Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.222 0.245
Expression system: Not provided

Quick links

Citations

16 review citations

A journey through the lectin pathway of complement-MBL and beyond.
Garred et al. (2016)
15 more

125 mentions without citation

Protein Data Bank (PDB): The Single Global Macromolecular Structure Archive.
Burley et al. (2017)
124 more