› 3dfl

X-ray diffraction
2Å resolution

Crystal structure of human Prostasin complexed to 4-guanidinobenzoic acid

Released:
DOI: 10.2210/pdb3dfl/pdb
PDB entry 3dfl coloured by chain, front view.
PDB entry 3dfl coloured by chain, side view.
PDB entry 3dfl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human prostasin, a target for the regulation of hypertension.
Rickert KW, Kelley P, Byrne NJ, Diehl RE, Hall DL, Montalvo AM, Reid JC, Shipman JM, Thomas BW, Munshi SK, Darke PL, Su HP
J Biol Chem 283 34864-72 (2008)
PMID: 18922802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172540 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostasin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 28.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16651 (Residues: 45-289; Coverage: 78%)
Gene name: PRSS8
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand GBS 1 x GBS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 53.498Å b: 54.846Å c: 83.279Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.173 0.225
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Serine proteases.
Di Cera E. (2009)
8 more

4 mentions without citation

Structure of human prostasin, a target for the regulation of hypertension.
Rickert et al. (2008)
3 more