› 3dhm

X-ray diffraction
1.8Å resolution

Beta 2 microglobulin mutant D59P

Released:
DOI: 10.2210/pdb3dhm/pdb
PDB entry 3dhm coloured by chain, front view.
PDB entry 3dhm coloured by chain, side view.
PDB entry 3dhm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
DE loop mutations affect beta2-microglobulin stability and amyloid aggregation.
Ricagno S, Colombo M, de Rosa M, Sangiovanni E, Giorgetti S, Raimondi S, Bellotti V, Bolognesi M
Biochem Biophys Res Commun 377 146-50 (2008)
PMID: 18835253

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 78.186Å b: 29.189Å c: 55.323Å
α: 90° β: 121.45° γ: 90°
R-values:
R R work R free
0.191 0.19 0.222
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator.
Li et al. (2016)
3 more

3 mentions without citation

Understanding the complex mechanisms of β2-microglobulin amyloid assembly.
Eichner et al. (2011)
2 more