› 3dlw

X-ray diffraction
2.7Å resolution

Antichymotrypsin

Released:
DOI: 10.2210/pdb3dlw/pdb
PDB entry 3dlw coloured by chain, front view.
PDB entry 3dlw coloured by chain, side view.
PDB entry 3dlw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification and characterization of a misfolded monomeric serpin formed at physiological temperature.
Pearce MC, Powers GA, Feil SC, Hansen G, Parker MW, Bottomley SP
J Mol Biol 403 459-67 (2010)
PMID: 20837024

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antichymotrypsin Chain: A
Molecule details ›
Chain: A
Length: 411 amino acids
Theoretical weight: 46.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01011 (Residues: 25-423; Coverage: 100%)
Gene names: AACT, GIG24, GIG25, SERPINA3
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 68.666Å b: 76.122Å c: 86.502Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.286
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.
Gettins et al. (2016)
5 other articles