› 3dtx

X-ray diffraction
2.1Å resolution

Crystal structure of HLA-B*2705 complexed with the double citrullinated vasoactive intestinal peptide type 1 receptor (VIPR) peptide (residues 400-408)

Released:
DOI: 10.2210/pdb3dtx/pdb
PDB entry 3dtx coloured by chain, front view.
PDB entry 3dtx coloured by chain, side view.
PDB entry 3dtx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Beltrami A, Gabdulkhakov A, Rossmann M, Ziegler A, Uchanska-Ziegler B, Saenger W

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-227542 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A3F718 (Residues: 11-286; Coverage: 93%)
Gene name: HLA-B
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Vasoactive intestinal polypeptide receptor 1 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P32241 (Residues: 400-408; Coverage: 2%)
Gene name: VIPR1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CIR 2 x CIR

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P21
Unit cell:
a: 50.842Å b: 81.931Å c: 65.771Å
α: 90° β: 108.88° γ: 90°
R-values:
R R work R free
0.212 0.209 0.262
Expression systems:
  • Escherichia coli
  • Not provided

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