› 3dwy

X-ray diffraction
1.98Å resolution

Crystal Structure of the Bromodomain of Human CREBBP

Released:
DOI: 10.2210/pdb3dwy/pdb
PDB entry 3dwy coloured by chain, front view.
PDB entry 3dwy coloured by chain, side view.
PDB entry 3dwy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: R3
Unit cell:
a: 121.484Å b: 121.484Å c: 40.378Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.159 0.219
Expression system: Escherichia coli

Quick links

Citations

244 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
243 more

13 mentions without citation

Protein lysine acetylation by p300/CBP.
Dancy et al. (2015)
12 more