› 3e17

X-ray diffraction
1.75Å resolution

Crystal structure of the second PDZ domain from human Zona Occludens-2

Released:
DOI: 10.2210/pdb3e17/pdb
PDB entry 3e17 coloured by chain, front view.
PDB entry 3e17 coloured by chain, side view.
PDB entry 3e17 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the second PDZ domain from human zonula occludens 2.
Chen H, Tong S, Li X, Wu J, Zhu Z, Niu L, Teng M
Acta Crystallogr Sect F Struct Biol Cryst Commun 65 327-30 (2009)
PMID: 19342771

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193697 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tight junction protein ZO-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 88 amino acids
Theoretical weight: 10.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UDY2 (Residues: 306-384; Coverage: 7%)
Gene names: TJP2, X104, ZO2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P1
Unit cell:
a: 30.177Å b: 41.325Å c: 41.292Å
α: 80.05° β: 68.63° γ: 68.52°
R-values:
R R work R free
0.208 0.206 0.237
Expression system: Escherichia coli

Quick links

Citations

2 review citations

ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis.
Gonzalez-Mariscal et al. (2012)
1 more

4 mentions without citation

Structural Features of Tight-Junction Proteins.
Heinemann et al. (2019)
3 more