› 3e7o

X-ray diffraction
2.14Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 360 amino acids
Theoretical weight: 41.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45984 (Residues: 7-362; Coverage: 84%)
Gene names: JNK2, MAPK9, PRKM9, SAPK1A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 35F 2 x 35F
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 161.688Å b: 78.784Å c: 78.927Å
α: 90° β: 96.43° γ: 90°
R-values:
R R work R free
0.219 0.217 0.25
Expression system: Escherichia coli

Quick links

Citations

4 review citations

JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities.
Mehan et al. (2011)
3 more

23 mentions without citation

Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinases.
Schnieders et al. (2012)
22 more