› 3edi

X-ray diffraction
1.4Å resolution

Crystal structure of tolloid-like protease 1 (TLL-1) protease domain

Released:
DOI: 10.2210/pdb3edi/pdb
PDB entry 3edi coloured by chain, front view.
PDB entry 3edi coloured by chain, side view.
PDB entry 3edi coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Mac Sweeney A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tolloid-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 23.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43897 (Residues: 148-348; Coverage: 20%)
Gene names: TLL, TLL1
Sequence domains: Astacin (Peptidase family M12A)
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

4 bound ligands:
Ligand ACE 1 x ACE
Ligand ZN 2 x ZN
Ligand SO4 3 x SO4
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 41.281Å b: 58.923Å c: 47.444Å
α: 90° β: 104.62° γ: 90°
R-values:
R R work R free
0.155 0.154 0.182
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists.
Rider et al. (2010)
5 more

2 mentions without citation

Architecture and function of metallopeptidase catalytic domains.
Cerdà-Costa et al. (2014)
1 more