› 3eed

X-ray diffraction
2.8Å resolution

Crystal structure of human protein kinase CK2 regulatory subunit (CK2beta; mutant 1-193)

Released:
DOI: 10.2210/pdb3eed/pdb
PDB entry 3eed coloured by chain, front view.
PDB entry 3eed coloured by chain, side view.
PDB entry 3eed coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The interaction of CK2alpha and CK2beta, the subunits of protein kinase CK2, requires CK2beta in a preformed conformation and is enthalpically driven.
Raaf J, Brunstein E, Issinger OG, Niefind K
Protein Sci 17 2180-6 (2008)
PMID: 18824508

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-159248 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P67870 (Residues: 1-193; Coverage: 90%)
Gene names: CK2N, CSNK2B, G5A
Sequence domains: Casein kinase II regulatory subunit
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P41212
Unit cell:
a: 116.463Å b: 116.463Å c: 76.088Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.172 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

How druggable is protein kinase CK2?
Cozza et al. (2010)
4 more

6 mentions without citation

Protein-protein docking benchmark version 4.0.
Hwang et al. (2010)
5 more