› 3efh

X-ray diffraction
2.6Å resolution

Crystal structure of human phosphoribosyl pyrophosphate synthetase 1

Released:
DOI: 10.2210/pdb3efh/pdb
PDB entry 3efh coloured by chain, front view.
PDB entry 3efh coloured by chain, side view.
PDB entry 3efh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li X, Peng X, Li Y

Function and Biology Details

Reaction catalysed: 
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo hexamer
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribose-phosphate pyrophosphokinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 326 amino acids
Theoretical weight: 35.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60891 (Residues: 1-318; Coverage: 100%)
Gene name: PRPS1
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: R3
Unit cell:
a: 169.18Å b: 169.18Å c: 61.84Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.231
Expression system: Escherichia coli

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