› 3efl

X-ray diffraction
2.2Å resolution

Crystal structure of the VEGFR2 kinase domain in complex with motesanib

Released:
DOI: 10.2210/pdb3efl/pdb
PDB entry 3efl coloured by chain, front view.
PDB entry 3efl coloured by chain, side view.
PDB entry 3efl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kim JL, Whittington DA, Long AM, Rose P, Gu Y, Zhao H

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P35968 (Residues: 815-1171; Coverage: 23%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 706 2 x 706
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 55.59Å b: 66.81Å c: 91.42Å
α: 90° β: 93.27° γ: 90°
R-values:
R R work R free
0.23 0.23 0.264
Expression system: Trichoplusia ni

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