› 3eh1

X-ray diffraction
1.8Å resolution

Crystal structure of the human COPII-coat protein Sec24b

Released:
DOI: 10.2210/pdb3eh1/pdb
PDB entry 3eh1 coloured by chain, front view.
PDB entry 3eh1 coloured by chain, side view.
PDB entry 3eh1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.
Mancias JD, Goldberg J
EMBO J 27 2918-28 (2008)
PMID: 18843296

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131942 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein transport protein Sec24B Chain: A
Molecule details ›
Chain: A
Length: 751 amino acids
Theoretical weight: 84.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O95487 (Residues: 518-1268; Coverage: 59%)
Gene name: SEC24B
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 161.37Å b: 67.5Å c: 72.44Å
α: 90° β: 100.37° γ: 90°
R-values:
R R work R free
0.184 0.184 0.218
Expression system: Spodoptera frugiperda

Quick links

Citations

44 review citations

COPII and the regulation of protein sorting in mammals.
Zanetti et al. (2012)
43 more

4 mentions without citation

The VSGB 2.0 model: a next generation energy model for high resolution protein structure modeling.
Li et al. (2011)
3 more